SIRT3 Antibody

NAD-dependent deacetylase sirtuin-3, mitochondrial is a protein that in humans is encoded by the SIRT3 gene. It is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. Endogenous SIRT3 is a soluble protein located in the mitochondrial matrix. Overexpression in cultured cells increases respiration and decreases the production of reactive oxygen species. It can function as a mitochondrial deacetylase. Additionally, human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.