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SynCAM Antibody

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. This gene is also known as IGSF4, SYNCAM or TSLC1, and it is mapped to 11q23.3. It functions as a homophilic cell adhesion molecule at the synapse. Expression of the isolated cytoplasmic tail of SynCAM in neurons inhibited synapse assembly. Conversely, expression of full-length protein in nonneuronal cells induced synapse formation by cocultured hippocampal neurons with normal release properties.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Human partial recombinant protein (AA 45-340) was used as the immunogen for this SynCAM antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the SynCAM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This SynCAM antibody is available for research use only.

Storage Conditions

After reconstitution, the SynCAM antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the SynCAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of SynCAM antibody and Lane 1: rat brain; 2: human HeLa; 3: (h) A549; 4: (h) Jurkat. Predicted molecular weight: ~48/37 kDa (isoforms 1/2) with N-linked and O-linked glycosylation each possibly adding ~25 kDa to the observed size.

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