What is the catalog number for NALP3 Antibody (NLRP3)?

The catalog number for NALP3 Antibody (NLRP3) is R31539.

What sizes are available for NALP3 Antibody (NLRP3)?

NALP3 Antibody (NLRP3) is available in the following size(s): 100 µg.

Is NALP3 Antibody (NLRP3) in stock?

NALP3 Antibody (NLRP3) is currently made to order / not held in immediate stock. Contact us for lead time.

NALP3 Antibody (NLRP3)

NLR Family, Pyrin domain containing 3, also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 gene. It is mapped to 1q44. The encoded protein may play a role in the regulation of inflammation and apoptosis. Consistent with an essential role for NALP3 inflammasomes in antifungal immunity, it has been showed that deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

Host

Rabbit

Reactivity

Human

Immunogen

Human partial recombinant protein (21-194) was used as the immunogen for this NLRP3 / NALP3 antibody.

Clonality

Polyclonal

Isotype

Ig

Applications

WB

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the NALP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This NALP3 antibody is available for research use only.

Storage Conditions

After reconstitution, the NALP3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Titration of the NALP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of NALP3 antibody and lysates from the human tumor cell lines 1: HeLa; 2: MCF-7; 3: Jurkat; 4: HEPG2. Predicted molecular weight ~118 kDa.