Cyclin B1 Antibody

Cyclin B1 is a protein that in humans is encoded by the CCNB1 gene, and it is mapped to 5q13.2. It is a regulatory protein involved in mitosis. The gene product complexes with<a href=../search_result.php?search_txt=cdc2>p34(Cdc2)</a>to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. CCNB1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and positive feedback loops ensure that once the<a href=../search_result.php?search_txt=cyclin b1>Cyclin B1</a>-<a href=../search_result.php?search_txt=cdk1>Cdk1</a>complex is activated, it is not deactivated.