PON1 Antibody

Paraoxonase 1, also known as Aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. This protein has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the gene significantly affect the catalytic ability of the enzyme. Paraoxonase 1 is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The gene is activated by PPAR-gamma, which increases synthesis and release of PON1 enzyme from the liver, reducing atherosclerosis.