PON1 Antibody
Paraoxonase 1, also known as Aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. This protein has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the gene significantly affect the catalytic ability of the enzyme. Paraoxonase 1 is also a major anti-atherosclerotic component of high-density lipoprotein (HDL) . The gene is activated by PPAR-gamma, which increases synthesis and release of PON1 enzyme from the liver, reducing atherosclerosis.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P27169
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the middle region of human Paraoxonase 1 (FLDPYLQSWEMYLGLA) was used as the immunogen for this PON1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
Limitations
This PON1 antibody is available for research use only.
Storage Conditions
Product Datasheet
https://www.nsjbio.com/tds-pdf/pon1-antibody-r31377
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Location
Cytoplasmic, secreted
Image Legend
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