What is the catalog number for PON1 Antibody?

The catalog number for PON1 Antibody is R31377.

What sizes are available for PON1 Antibody?

PON1 Antibody is available in the following size(s): 100 µg.

Is PON1 Antibody in stock?

PON1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

PON1 Antibody

Paraoxonase 1, also known as Aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. This protein has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the gene significantly affect the catalytic ability of the enzyme. Paraoxonase 1 is also a major anti-atherosclerotic component of high-density lipoprotein (HDL) . The gene is activated by PPAR-gamma, which increases synthesis and release of PON1 enzyme from the liver, reducing atherosclerosis.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

P27169

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

An amino acid sequence from the middle region of human Paraoxonase 1 (FLDPYLQSWEMYLGLA) was used as the immunogen for this PON1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

Reconstitution

After reconstitution, the PON1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This PON1 antibody is available for research use only.

Storage Conditions

After reconstitution, the PON1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the PON1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Location

Cytoplasmic, secreted

Image Legend

Western blot testing of PON1 antibody and Lane 1: rat liver; 2: (r) lung; 3: human placenta; 4: (r) testis; 5: (h) HeLa; 6: mouse HEPA; 7: (h) A549; 8: (h) Jurkat; 9: (h) SKOV lysate. Expected/observed molecular weight ~40 kDa.