ZBP1/RIP3/MLKL activator 1

ZBP1/RIP3/MLKL activator 1 (compound 3a) is a synthetically derived quinoline compound. ZBP1/RIP3/MLKL Activator 1 induces DNA damage, enhances intracellular levels of reactive oxygen species (ROS), and triggers apoptosis via the caspase pathway. Furthermore, when apoptosis is inhibited, ZBP1/RIP3/MLKL Activator 1 promotes necroptotic cell death through the ZBP1-RIP3-MLKL pathway. ZBP1/RIP3/MLKL Activator 1 is utilized in oncological research, particularly in the selective targeting of cells with impaired apoptotic function[1].

Product Specifications

UNSPSC

12352005

Target

Mixed Lineage Kinase; Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zbp1-rip3-mlkl-activator-1.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCCNC1=NC2=CC([N+]([O-])=O)=CC=C2N=C1NCC3=CC=C(C4=CC=CC=C4)C=C3

Molecular Formula

C26H28N6O2

Molecular Weight

456.54

References & Citations

[1]Saha R, et al. Mono-quinoxaline-induced DNA structural alteration leads to ZBP1/RIP3/MLKL-driven necroptosis in cancer cells[J]. European Journal of Medicinal Chemistry, 2024, 270: 116377.