ADAMTS1 Antibody

A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1, also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix (ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott (2000) mapped the gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al. (1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al. (1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.