CSF1R Antibody / Colony Stimulating Factor 1 Receptor

Colony-Stimulating Factor 1 Receptor also known as MCSFR, FMS, c-FMS, and CD115, encodes a tyrosine kinase growth factor receptor for colony-stimulating factor-1, the macrophage-and monocyte-specific growth factor. The gene is located on long arm of chromosome 5(5q32) on the Crick(minus) strand. The as-yet-unidentifiedCSF1R promoter/enhancer sequences may be confined to the nucleotides separating the 2 genes or could potentially lie within the PDGFR gene itself. The encoded protein is a single pass type I membrane protein and acts as the receptor forcolony stimulating factor 1, a cytokine which controls the production, differentiation, and function ofmacrophages. The protein is a tyrosine kinasetransmembrane receptorand member of the CSF1/PDGF receptorfamily of tyrosine-protein kinases.Kondo et al.(2000)showed that the endogenous myelomonocytic cytokine receptors for GM-CSF and macrophage colony-stimulating factor are expressed at low to moderate levels on the more primitive hematopoietic stem cells, are absent on common lymphoid progenitors, and are upregulated after myeloid lineage induction by IL-2.