ERBB3 Antibody (HER3)

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3, also known as HER3, is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. By in situ hybridization, Kraus et al. (1989) mapped the gene to chromosome 12q13. Carraway et al. (1994) demonstrated that ERBB3 is a receptor for Heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Most notably, EGFR and ERBB2 became markedly more promiscuous as the threshold was lowered, whereas ERBB3 did not. Engelman et al. (2007) found that amplification of MET caused gefitinib resistance by driving ERBB3-dependent activation of phosphoinositide 3-kinase, a pathway though to be specific to EGFR/ERBB family receptors.