Lawsone
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research[1][2][3][4][5].
Product Specifications
CAS Number
83-72-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/lawsone.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(O)=CC(C2=C1C=CC=C2)=O
Molecular Formula
C10H6O3
Molecular Weight
174.16
Precautions
H315, H319, H335
References & Citations
[1]Tripathi RD, et al. A fungitoxic principle from the leaves of lawsonia inermis lam. Experientia. 1978 Jan 15;34 (1) :51-2.|[2]Munday R, et al. Haemolytic activity and nephrotoxicity of 2-hydroxy-1,4-naphthoquinone in rats. J Appl Toxicol. 1991 Apr;11 (2) :85-90.|[3]Sauriasari R, et al. Cytotoxicity of lawsone and cytoprotective activity of antioxidants in catalase mutant Escherichia coli. Toxicology. 2007 Jun 3;235 (1-2) :103-11.|[4] Wang SB, et al. Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-κB pathway. Biomed Pharmacother. 2017 May;89:152-161.|[5]Li P, et al. Lawsone inhibits cell growth and improves the efficacy of cisplatin in SKOV-3 ovarian cancer cell lines. African Journal of Traditional, Complementary and Alternative Medicines, 2017, 14 (5) : 8-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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