HSPA2 Antibody

Heat shock 70kDa protein 2 is also known as HSP70-2 and HSPA2. Analysis of the sequence indicated that HSPA2 is the human homolog of the murine Hsp70-2 gene, with 91.7% identity in the nucleotide coding sequence and 98.2% in the corresponding amino acid sequence. HSPA2 has less amino acid homology to the other members of the human HSP70 gene family. It is constitutively expressed in most tissues, with very high levels in testis and skeletal muscle. The gene is located on chromosome 14q22-q24. Immunohistochemical analysis detected weak expression of HSPA2 in spermatocytes and stronger expression in spermatids and in the tail of mature sperm. The protein may be critical to sperm maturation through its role as a protein chaperone.