GSK729
GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model.
Product Specifications
CAS Number
[1403602-92-5]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gsk729.html
Smiles
O=C(O)C1=C2N[C@H](C[C@H](N2N=C1)C(F)(F)F)C3=CC=C(C=C3)CC
Molecular Formula
C16H16F3N3O2
Molecular Weight
339.31
References & Citations
[1]THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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