HSF2 Antibody / Heat shock factor 2

Heat shock transcription factor 2 is a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Mouse HSF2 was expressed in all three embryonic layers at embryonic day 7.5 and the head fold was strongly stained at embryonic day 8.5. In adults, expression is detected in spermatocytes and spermatogonia, but not in elongated spermatids, spermatozoa, or Sertoli cells. It mediates Hsp70i bookmarking, binding to this promoter in mitotic cells, recruits protein phosphatase-2A, and interacts with the CAPG subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. And HSF2-null mice were born at the expected mendelian ratio but had brain abnormalities and meiotic and gametogenic defects in both genders.