SCF Antibody / KITLG
Stem Cell Factor (also called kit-ligand, KL1, and Steel factor) is a cytokine that binds to the c-Kit receptor (CD117) . SCF can exist both as a transmembrane protein and a soluble protein. It is localized to the long arm of human chromosome 12, between 12q14.3 and 12qter. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. It has been shown to increase the survival of HSCs in vitro and contributes to the self renewal and maintenance of HSCs in-vivo. HSCs at all stages of development express the same levels of the receptor for SCF (c-Kit) . The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P21583
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 26-44 (DEGICRNRVTNNVKDVTKLV-human) were used as the immunogen for this SCF antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide/thimerosal
Reconstitution
Limitations
This SCF antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of SCF antibody and Lane 1: recombinant human protein 10ng; 2: 5ng; 3: 2.5ng
Documents
Frequently Asked Questions
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