IL-23 Antibody (p19/alpha subunit)

Interleukin-23 is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit) . The International Radiation Hybrid Mapping Consortium mapped the IL-23 gene to chromosome 12. The cytokine is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q9EQ14

Host

Rabbit

Reactivity

Mouse

Immunogen

An amino acid sequence from the N-terminus of mouse IL-23 (p19/alpha subunit, amino acids DWAQCQQLSRNLCMLAWNAH) was used as the immunogen for this IL-23 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

Reconstitution

After reconstitution, the IL23 p19 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This IL-23 antibody is available for research use only.

Storage Conditions

After reconstitution, the IL-23 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the IL-23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.