C-Fos Antibody

The human oncogene c-Fos is the cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. The protein is encoded by the FOS gene. It was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-Fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.