TIMP4 Antibody
The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. The TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL
UniProt
Q99727
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 208-224 (YRGHLPLRKEFVDIVQP-human) were used as the immunogen for this TIMP4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
Store the TIMP4 antibody at -20oC.
Limitations
This TIMP4 antibody is available for research use only.
Storage Conditions
Store the TIMP4 antibody at -20°C.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Location
Secreted
Image Legend
Western blot testing of TIMP4 antibody and Lane 1: rat kidney; 2: human MCF-7; Predicted/observed molecular weight: ~25 kDa.
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