CD40 Antibody

CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

P27512

Host

Rabbit

Reactivity

Mouse

Immunogen

An amino acid sequence from the N-terminus of mouse CD40 (QCVTCSDKQYLHDGQ) was used as the immunogen for this CD40 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA, 0.025% thimerosal and 0.005% sodium azide

Reconstitution

Store the CD40 antibody at -20oC.

Limitations

This CD40 antibody is available for research use only.

Storage Conditions

Store the CD40 antibody at -20°C.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the CD40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.