CBS Antibody / Cystathionine Beta Synthase
Cystathionine-beta-synthase is an enzyme that in humans is encoded by the CBS gene. It is mapped to 21q22.3 and contains 23 exons, ranging in size from 42 to 299 bp. CBS catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. It uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet) . This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. It is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The gene is the most common locus for mutations associated with homocystinuria.
Product Specifications
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human partial recombinant protein (AA 331-551) was used as the immunogen for this CBS antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Limitations
This CBS antibody is available for research use only.
Storage Conditions
Product Datasheet
https://www.nsjbio.com/tds-pdf/cbs-antibody-cystathionine-beta-synthase-r30143
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
CAS Number
9007-83-4
Location
Nuclear, cytoplasmic
Image Legend
IHC staining of FFPE human liver cancer tissue with CBS antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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