Neurofilament Antibody (Light)
Neurofilaments are composed of three neuron-specific proteins with apparent molecular masses of 68kD (NFL), 125kD (NFM) and 200kD (NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. NF68, also called Neurofilament Protein Light (NFL) is one of the most abundant cytoskeletal components of the neuron. Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E (CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, IHC (FFPE) : 2-4 µg/mL, IHC (Frozen) : 2-4 µg/mL; formalin or acetone fixed tissues
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Pig spinal cord was used as the immunogen for this light Neurofilament antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
NR4
Applications
WB, IHC-P, IHC-F
Purity
Ascites
Format
Ascites
Buffer
0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Reconstitution
Limitations
This Neurofilament antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1X PBS
Applications Notes
Location
Cytoplasmic, membranous
Image Legend
Documents
Frequently Asked Questions
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