DRAM Antibody
Autophagy is the mechanism by which lysosomes degrade unneeded or dysfunctional cellular components. p53 is a tumor suppressor protein that modulates autophagy and apoptosis. DRAM, or damage regulated autophagy modulator, is a lysosomal protein and effector of p53-mediated cell death. Many tumors show decreased DRAM expression and siRNA knockdown resulted in reduced cell death (Crighton et al, 2006).
Product Specifications
Host
Rabbit
Immunogen
A recombinant protein fragment from the N-terminal region of human DRAM was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Purified
Buffer
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the DRAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DRAM antibody is available for research use only.
CAS Number
9007-83-4
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