DRAM Antibody
Autophagy is the mechanism by which lysosomes degrade unneeded or dysfunctional cellular components. p53 is a tumor suppressor protein that modulates autophagy and apoptosis. DRAM, or damage regulated autophagy modulator, is a lysosomal protein and effector of p53-mediated cell death. Many tumors show decreased DRAM expression and siRNA knockdown resulted in reduced cell death (Crighton et al, 2006) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 4-8 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the N-terminal region of human DRAM was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the DRAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DRAM antibody is available for research use only.
Storage Conditions
Aliquot the DRAM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples using DRAM antibody at 4ug/ml.
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