TAB3 Antibody
TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs) . TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 4-8 µg/mL
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A purified antibody
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the TAB3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TAB3 antibody is available for research use only.
Storage Conditions
Aliquot the TAB3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples with TAB3 antibody at 4ug/ml.
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