CYLD Antibody
CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 2-5 µg/mL
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the CYLD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CYLD antibody is available for research use only.
Storage Conditions
Aliquot the CYLD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples with CYLD antibody at 2ug/ml. Predicted molecular weight ~107kDa.
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