CYLD Antibody
CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
Product Specifications
Host
Rabbit
Immunogen
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Purified
Buffer
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CYLD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CYLD antibody is available for research use only.
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
