Viperin Antibody
Viral infection induces the interferon (IFN) response which triggers the production of an array of anti-viral proteins. Viperin (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is expressed in response to IFN-b binding to the IFN receptor, inducing the formation of the IFN-stimulated gene factor 3 complex which then binds to the Viperin promoter. It inhibits many DNA and RNA viruses through a diverse range of mechanisms and is involved in the PRR-mediated innate immune response. Viperin has been shown to be produced in response to TLR3 and TLR4 activation, but not TLR2 and TLR5. It may be involved in the TLR7 and TLR9-induced production of type I IFN by plasmacytoid dendritic cells (pDCs) .
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 3-6 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
A recombinant protein fragment from the N-terminal region of human Viperin was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography purified antibody
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the Viperin antibody and store frozen at -20oC or colder to avoid repeated freeze-thaw cycle.
Limitations
This Viperin antibody is available for research use only.
Storage Conditions
Aliquot the Viperin antibody and store frozen at -20°C or colder to avoid repeated freeze-thaw cycle.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, Viperin antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples using Viperin antibody at 3ug/ml.
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