ATF6 Antibody
ER stress can cause the accumulation of unfolded proteins and lead to the activation of the UPR (unfolded proetin response). Cells have developed an intracellular signaling pathway to deal with this stress, and Activating Transcription Factor 6 (ATF6) is a major transducer of the UPR. Upon activation, ATF6 seperates from GPR78 and is cleaved. The ~50 kD cytosolic portion of ATF6 translocates to the nucleus, transmitting the ER stress signal. In the nucleus, ATF6 activates the transcription of UPR-responsive genes by biniding to their ERSE (ER stress response element) region.
Product Specifications
Host
Mouse
Immunogen
A recombinant protein fragment from the N-terminal region of human ATF6 was used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB, IHC-P
Format
Purified
Buffer
0.5 mg/ml antibody in PBS with 0.1 mg/ml BSA (US source) and 0.05% sodium azide
Reconstitution
Aliquot the antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ATF6 antibody is available for research use only.
CAS Number
9007-83-4
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