Survivin Antibody / BIRC5
Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 2-5 µg/mL
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Survivin antibody is available for research use only.
Storage Conditions
Aliquot the antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples with Survivin antibody at 2ug/ml. Predicted molecular weight ~16 kDa.
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