CLEC4E Antibody
CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRγ , and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 2-5 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the CLEC4E antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CLEC4E antibody is available for research use only.
Storage Conditions
Aliquot the CLEC4E antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples with CLEC4E antibody at 2ug/ml.
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