EDG1 Antibody
EDG1 (Endothelial differentiation gene 1), also called Sphingosine-1-phosphate receptor 1 (S1PR1) is the G-protein coupled receptor for Sphingosine 1-phosphate (S1P) . Via its interaction with S1P, EDG1 is involved in a number of cellular processes. The binding of S1P leads to angiogenesis and tumor cell motility in cancer, and this interaction also participates in the formation of cell-cell adherens junctions. During embryogenesis, it regulates vascularization. EDG1 interacts with the serotonin receptor 5-HT1AR in the central nervous system. It is also a regulator of innate and adaptive immunity by signaling the release of T-cells from lymph nodes.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 4-6 µg/mL
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the C-terminal portion of human EDG1 was used as the immunogen for this antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Aliquot the EDG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This EDG1 antibody is available for research use only.
Storage Conditions
Aliquot the EDG1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Provided assay concentrations are suggestions only, EDG1 antibody titration may be required for optimal results.
Image Legend
Western blot testing of human samples with EDG1 antibody at 4ug/ml.
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