IKKb Antibody
NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
Product Specifications
Host
Mouse
Immunogen
A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB
Format
Purified
Buffer
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IKKb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IKKb antibody is available for research use only.
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
PE-Linked Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1)
PE-Linked Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1)
PE-Linked Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1)
PE-Linked Polyclonal Antibody to Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1)