Cytochrome P450 3A5 Antibody / CYP3A5

CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:500-1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry (FFPE) : 1:10-1:50

UniProt

P20815

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 476-502 from the human protein was used as the immunogen for the Cytochrome P450 3A5 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IF, IHC-P

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Cytochrome P450 3A5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Cytochrome P450 3A5 antibody is available for research use only.

Storage Conditions

Aliquot the Cytochrome P450 3A5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the Cytochrome P450 3A5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.