ErbB2 Antibody / HER2

ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1:50-1:100, Western blot: 1:500-1:1000

UniProt

P04626

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 1206-1236 from the human protein was used as the immunogen for the ErbB2 antibody.

Clonality

Polyclonal

Isotype

Applications

IHC-P, WB

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This ErbB2 antibody is available for research use only.

Storage Conditions

Aliquot the ErbB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.