VCL Antibody / Vinculin
VCL/Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:10-1:50
UniProt
P18206
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 12-39 from the human protein was used as the immunogen for the VCL antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the VCL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This VCL antibody is available for research use only.
Storage Conditions
Aliquot the VCL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Western blot testing of 1) human RD, 2) human HeLa, 3) rat liver and 4) human testis lysate with VCL antibody. Predicted molecular weight ~124 kDa.
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