Deoxycytidine kinase Antibody / DCK
Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry (FFPE) : 1:10-1:50
UniProt
P27707
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 171-200 from the human protein was used as the immunogen for the Deoxycytidine kinase antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, IHC-P
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Deoxycytidine kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Deoxycytidine kinase antibody is available for research use only.
Storage Conditions
Aliquot the Deoxycytidine kinase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of mouse intestine tissue lysate with Deoxycytidine kinase antibody. Predicted molecular weight ~31 kDa.
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