Inhibin alpha Antibody / INHA
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:1000, Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:10-1:50, Immunofluorescence: 1:10-1:50
UniProt
P05111
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 79-108 from the human protein was used as the immunogen for the Inhibin alpha antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC-P, IF
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Inhibin alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Inhibin alpha antibody is available for research use only.
Storage Conditions
Aliquot the Inhibin alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear and Cytoplasmic (secreted)
Image Legend
Flow cytometry testing of human HEK293 cells with Inhibin alpha antibody; Blue=isotype control, Green= Inhibin alpha antibody.
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