GZMB Antibody / Granzyme B
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100
UniProt
P10144
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 175-203 from the human protein was used as the immunogen for the GZMB antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, WB, IHC-P
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GZMB antibody is available for research use only.
Storage Conditions
Aliquot the GZMB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Flow cytometry testing of human HL60 cells with GZMB antibody; Blue=isotype control, Green= GZMB antibody.
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