IL1RN Antibody / IL1RA / Interleukin-1 Receptor Antagonist

The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of its gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.

Product Specifications

CAS Number

9007-83-4

Specifications

Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunofluorescence: 1:10-1:50, Immunohistochemistry (FFPE) : 1:10-1:50, Western blot: 1:500-1:1000

UniProt

P18510

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 100-129 from the human protein was used as the immunogen for the IL1RN antibody.

Clonality

Polyclonal

Isotype

Applications

FACS, IF, IHC-P, WB

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the IL1RN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This IL1RN antibody is available for research use only.

Storage Conditions

Aliquot the IL1RN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the IL1RN antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Location

Cytoplasmic

Image Legend

IHC testing of FFPE human colon carcinoma tissue with IL1RN antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.