Beta-secretase 1 Antibody / Memapsin-2 / BACE1C

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the BACE1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 (1x10e6 cells), Western blot: 1:500-1:1000

UniProt

P56817

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 125-154 from the human protein was used as the immunogen for the Beta-secretase 1 antibody.

Clonality

Polyclonal

Isotype

Applications

IHC-P, FACS, WB

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Beta-secretase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Beta-secretase 1 antibody is available for research use only.

Storage Conditions

Aliquot the Beta-secretase 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the Beta-secretase 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.