PPIA Antibody / Cyclophilin A
PPIA is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:10-1:50, Western blot: 1:500-1:1000
UniProt
P62937
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 8-37 from the human protein was used as the immunogen for the PPIA antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PPIA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PPIA antibody is available for research use only.
Storage Conditions
Aliquot the PPIA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of human 1) A431 and 2) HeLa cell lysate with PPIA antibody. Predicted molecular weight ~18 kDa.
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