HBS1L Antibody

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:500-1:1000

UniProt

Q9Y450

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 460-486 from the human protein was used as the immunogen for the HBS1L antibody.

Clonality

Polyclonal

Isotype

Applications

Purity

Antigen affinity purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the HBS1L antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This HBS1L antibody is available for research use only.

Storage Conditions

Aliquot the HBS1L antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the HBS1L antibody may be required due to differences in protocols and secondary/substrate sensitivity.