HDAC11 Antibody

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25

UniProt

Q96DB2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 1-30 from the human protein was used as the immunogen for the HDAC11 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC-P

Purity

Purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the HDAC11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This HDAC11 antibody is available for research use only.

Storage Conditions

Aliquot the HDAC11 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the HDAC11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.