HDAC11 Antibody
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25
UniProt
Q96DB2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 1-30 from the human protein was used as the immunogen for the HDAC11 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HDAC11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HDAC11 antibody is available for research use only.
Storage Conditions
Aliquot the HDAC11 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Predominantly nuclear
Image Legend
Western blot testing of human Jurkat cell lysate with HDAC11 antibody. Predicted molecular weight ~39 kDa.
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