PXR Antibody / NR1I2
NR1I2/PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:25, Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
O75469
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 100-127 from the human protein was used as the immunogen for the PXR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, FACS, IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PXR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PXR antibody is available for research use only.
Storage Conditions
Aliquot the PXR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear
Image Legend
Western blot testing of human HL60 cell lysate with PXR antibody. Predicted molecular weight ~50 kDa.
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