FGR Antibody / c-FGR proto oncogene
FGR is a member of the Src family of protein tyrosine kinases (PTKs) . This protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:25, Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
P09769
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 3-33 from the human protein was used as the immunogen for the FGR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC-P, WB
Purity
SAS precipitation
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the FGR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FGR antibody is available for research use only.
Storage Conditions
Aliquot the FGR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Western blot testing of human Raji cell lysate with FGR antibody. Predicted molecular weight: ~59 kDa, routinely observed at 55~59 kDa.
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