FGR Antibody / c-FGR proto oncogene

FGR is a member of the Src family of protein tyrosine kinases (PTKs) . This protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunofluorescence: 1:25, Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000

UniProt

P09769

Host

Rabbit

Reactivity

Human

Immunogen

A portion of amino acids 3-33 from the human protein was used as the immunogen for the FGR antibody.

Clonality

Polyclonal

Isotype

Applications

IF, IHC-P, WB

Purity

SAS precipitation

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the FGR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This FGR antibody is available for research use only.

Storage Conditions

Aliquot the FGR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the FGR antibody may be required due to differences in protocols and secondary/substrate sensitivity.