MLF1 Antibody / Myeloid leukemia factor 1
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Flow cytometry: 1:25 (1x10e6 cells), Western blot: 1:500-1:2000
UniProt
P58340
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 215-244 from the human protein was used as the immunogen for the MLF1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, FACS, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the MLF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MLF1 antibody is available for research use only.
Storage Conditions
Aliquot the MLF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Image Legend
Western blot testing of human MCF7 lysate with MLF1 antibody. Predicted molecular weight ~31 kDa.
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