AADC Antibody / DOPA Decarboxylase / DDC

This protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) . AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency.

Product Specifications

CAS Number

9007-83-4

Specifications

Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000, Immunofluorescence: 1:25

UniProt

P20711

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 32-61 from the human protein was used as the immunogen for the AADC antibody.

Clonality

Polyclonal

Isotype

Applications

FACS, IHC-P, WB, IF

Purity

Antigen affinity purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the AADC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This AADC antibody is available for research use only.

Storage Conditions

Aliquot the AADC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the AADCantibody may be required due to differences in protocols and secondary/substrate sensitivity.