NUDT15 Antibody / Nudix hydrolase 15
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity) . May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
Q9NV35
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 89-118 from the human protein was used as the immunogen for the NUDT15 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NUDT15 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NUDT15 antibody is available for research use only.
Storage Conditions
Aliquot the NUDT15 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Cytoplasmic
Image Legend
Western blot testing of human SW620 cell lysate with NUDT15 antibody. Predicted molecular weight ~19 kDa.
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