NUDT15 Antibody / Nudix hydrolase 15

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity) . May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

Product Specifications

CAS Number

9007-83-4

Specifications

Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000

UniProt

Q9NV35

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A portion of amino acids 89-118 from the human protein was used as the immunogen for the NUDT15 antibody.

Clonality

Polyclonal

Isotype

Applications

FACS, IHC-P, WB

Purity

Antigen affinity purified

Format

Purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the NUDT15 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This NUDT15 antibody is available for research use only.

Storage Conditions

Aliquot the NUDT15 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

The stated application concentrations are suggested starting points. Titration of the NUDT15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.