CBS Antibody / Cystathionine Beta Synthase
CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25, Immunofluorescence: 1:25, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
P35520
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A portion of amino acids 301-330 from the human protein were used as the immunogen for the CBS antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF, FACS
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CBS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CBS antibody is available for research use only.
Storage Conditions
Aliquot the CBS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear, cytoplasmic
Image Legend
IHC testing of FFPE human brain tissue with CBS antibody. HIER: steam section in pH9 EDTA for 20 min and allow to cool prior to staining.
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